MS is frequently associated with grief, demoralization, temporary changes in self-esteem and body image, and clinical depression. These emotional challenges temporarily dampen sexual interest and pleasure. Coping with emotional changes to enhance sexuality has several aspects: professional assessment, education, treatment, and learning coping interventions. (Foley & Werner, 2000). Medications and psychotherapy usually offer relief from clinical depression, which restores sexual interest. However, some anti-depressants including Prozac® and Zoloft®, can cause loss of libido. Consulting with your physician about potential sexual side effects is important before anti-depressant therapy begins.

Temporary changes in self-esteem are frequently associated with the normal grieving that occurs in response to losses imposed by chronic illness. This normal grieving process tends to ebb and flow as the person works to redefine him- or herself in the face of MS. Education about MS, and comparing one's experience with others in education or support groups can be helpful. Exploring new options and discussing disappointments may be particularly difficult in the face of coping with all of the other changes associated with MS. MS peer groups, couples' groups, and/or counselling can facilitate the adaptation process.