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The relationship between infratentorial lesions, balance deficit and accidental falls in multiple sclerosis

This study from Italy investigates the relationship between static posturography measures and infratentorial MRI abnormalities. The study results suggested that those patients with greater brainstem and middle cerebellar peduncle T2 lesion volumes were at greater risk of falls. The same patient group also had the highest EDSS scores. The authors suggest that infratentorial T2 lesion volumes may be a useful investigation parameter when selecting patients requiring a proper rehabilitation intervention programme.

authors: Prosperini L, Kouleridou A, Petsas N, Leonardi L, Tona F, Pantano P, Pozzilli C.

source: J Neurol Sci. 2011 May 15;304(1-2):55-60. Epub 2011 Mar 12.

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Brain plasticity in relapsing-remitting multiple sclerosis: Evidence from resting-state fMRI

This interesting fMRI study compares the resting state brain activity amplitudes in patients with RRMS with healthy controls, and found they were significantly increased in areas with extensive cortical connections such as the thalami. The authors hypothesize that this is an adaptive phenomenon, reflecting either ongoing cortical plasticity in the resting state, or increased neuronal activity related to coordination of remapped cortical functions.

authors: Liu Y, Liang P, Duan Y, Jia X, Yu C, Zhang M, Wang F, Zhang M, Dong H, Ye J, Butzkueven H, Li K.

source: J Neurol Sci. 2011 May 15;304(1-2):127-31. Epub 2011 Feb 23.

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NOS2A as a candidate gene in relapsing-remitting multiple sclerosis: A haplotype study using selected subsets of single nucleotide polymorphisms

The authors investigated 13 single nucleotide polymorphisms in the nitric oxide synthase 2A (NOS2A) gene, as previous data from genome-wide screens have implicated the NOS2A, which encodes the inducible form of nitric oxide synthase, as being potentially associated with MS. In a study of 214 Italian patients with MS and 121 controls, no significant association between cases and controls (P>0.05) was observed, leading the authors to conclude that polymorphic variation within the NOS2A gene does not influence the susceptibility to MS in patients of Italian origin.

authors: Manna I, Liguori M, Valentino P, Vena L, Condino F, Nisticò R, Di Palma G, Quattrone A, Gambardella A.

source: J Neurol Sci. 2011 May 15;304(1-2):75-7. Epub 2011 Mar 3.

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