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MS in focus on spasticity coming soon

Issue 12 of MS in focus will be published soon. This edition of our biannual magazine looks at spasticity in MS and why it occurs, how it is evaluated, measured and treated, and options for rehabilitation.

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Profile of the Month : August 2008

Country: Canada
Age: 75
Occupation: Retired Union Representative
Type of MS: Primary progressive
Year of diagnosis: 1976

I have seen many positive changes in the way governments at every level in Canada have responded to people with MS; however, we still have a long way to go.

Read the full article here:

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Gray matter atrophy in multiple sclerosis: A longitudinal study

In this longitudinal study the authors looked at changes in grey matter in people with MS over four years. They found that grey matter changes were more prominent than white matter changes, especially as the disease progresses, and related to clinical outcome.

authors: Fisher E, Lee JC, Nakamura K, Rudick RA.

source: Ann Neurol. 2008 Jul 25.

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Helminth infections associated with multiple sclerosis induce regulatory B cells

In MS the immune system reacts against brain and spinal cord. The authors of this study observed that people with MS who had parasitic infections had less strong immune reactions. They suggested that it might explain why MS is less common in countries with high rates of parasitic infections.

authors: Correale J, Farez M, Razzitte G

source: Ann Neurol. 2008 Jul 24

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Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

This work looked at the proteins involved in the brain inflammation which occurs in people with MS. The authors suggested that these proteins might play an important role in MS and could be a good target for future treatments.

authors: Andersson A, Covacu R, Sunnemark D, Danilov AI, Dal Bianco A, Khademi M, Wallström E, Lobell A, Brundin L, Lassmann H, Harris RA.

source: J Leukoc Biol. 2008 Jul 21.

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Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis

It is thought that low vitamin D levels might be involved in the pathogenesis of MS. In this study the authors investigated a gene related to vitamin D. They found some relationship with clinical outcome.

authors: Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban PR, Rukin N, Alldersea J, Strange RC, Hawkins CP.

source: Mult Scler. 2008 Jul 24.

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European Neurological Society Fellowship

Deadline 15 October 2008

The ENS is offering a fellowship for an experimental project in neurology for the year 2009.

For more details and an application form, please click here.

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Two new cases of PML develop in people with MS taking Tysabri

source: US National MS Society

Biogen Idec and Elan Pharmaceuticals informed drug regulatory authorities about two new confirmed cases of PML in individuals who were taking Tysabri® (natalizumab) as a monotherapy (not in combination with other therapies).

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