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MSIF seeks Research Officer

MSIF seeks a Medical & Scientific Research Officer to manage our research-related projects and programmes. Appointment will be on a Fixed Term Contract (maternity cover) for one year, starting in January 2011. Applicants should be educated to postgraduate degree level in a relevant subject. Good organisational skills are essential, as is the ability to work to deadlines.

Find out more and apply

Meeting of the International Pediatric MS Study Group

The annual meeting of the Steering Committee of the International Pediatric MS Study Group (IPMSSG) was held in London, UK on the 25-26 September.

The meeting was co-hosted by MSIF, the US National MS Society and the MS Society of Canada.

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Stem Cells and MS: Booklet now available in Spanish

A booklet giving guidance on stem cell treatments for people affected by MS is now available in Spanish.

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New language editions of MS in focus on employment now available

The latest edition of MS in focus, looking in detail at employment and MS, is now available in German, French, Spanish and English.

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Last chance to have your say

Two surveys – on MS in focus magazine and MS research - are closing soon. If you haven't done so yet, please take the surveys and tell us your views.

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Profile of the Month : April 2011

Jeiab Allgallabi

Name: Jeiab Allgallabi
Country: Yemen
Occupation: Retired civil servant
Age: 37
Type of MS: Relapsing-remitting

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3 Tesla and 7 Tesla MRI of multiple sclerosis cortical lesions

The authors compared the agreement between imaging sequences at 3 Tesla (T) and 7T for the presence and appearance of individual multiple sclerosis cortical lesions. They found good agreement between images for the presence of mixed cortical lesions (involving both gray and white matter). However, agreement between imaging sequences was less good for purely intracortical lesions. Overall high resolution 7T imaging was found to be superior at anatomical localization of lesions in relation to the cortical boundary.

authors: Tallantyre EC, Morgan PS, Dixon JE, Al-Radaideh A, Brookes MJ, Morris PG, Evangelou N.

source: J Magn Reson Imaging. 2010 Oct;32(4):971-7.

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Gene expression changes in multiple sclerosis relapse suggest activation of T and non-T cells

The authors used microarrays to measure mRNA expression in paired samples from 14 MS patients during clinical relapse. The most notable finding was decreased expression of transcripts with regulatory function, expressed primarily in non-T cells. These decreased transcripts included the interleukin-1 receptor antagonist, which had a corresponding decrease in the protein concentration in serum. Transcripts with increased expression were primarily expressed in T cells. The authors have therefore concluded that during MS relapses changes occur in mRNA expression in both T cells and non-T cells.

authors: Lindsey JW, Agarwal SK, Tan FK.

source: Mol Med. 2010 Sep 17. [Epub ahead of print]

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Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency

The authors conducted an interesting examination of CSF ferritin levels in patients with all sub-types types of MS and a range of other neurological disorders to investigate the role of venous stasis related parenchymal iron deposition in pathogenesis of MS. In MS patients, there was no significant change of CSF ferritin levels over the 3-year follow-up period. The data from this study therefore does not support an etiologic role for CCSVI-related parenchymal iron deposition in MS.

authors: Worthington V, Killestein J, Eikelenboom MJ, Teunissen CE, Barkhof F, Polman CH, Uitdehaag BM, Petzold A.

source: Neurology. 2010 Sep 29. [Epub ahead of print]

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Risk of Arterial Cardiovascular Diseases in Patients with Multiple Sclerosis: A Population-Based Cohort Study

Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited. Researchers from Denmark conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched population cohort (n = 66,407) and calculated the risk of arterial cardiovascular disease (CVD) for all subjects.

Adjusted incidence rate ratios at 1yr follow up and subsequent 2-30 year follow up for myocardial infarction (MI), overall stroke rate, heart failure and atrial fibrillation/flutter were calculated. In this Danish cohort, the risk of CVD among MS patients was low, but greater than that in the general population, particularly in the short term.

authors: Christiansen CF, Christensen S, Farkas DK, Miret M, Sørensen HT, Pedersen L.

source: Neuroepidemiology. 2010 Sep 24;35(4):267-274. [Epub ahead of print]

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MS societies hold Annual Conferences

Several MS societies held their Annual Conferences and Patient Congresses in September.

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Multiple Sclerosis International Federation
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Email: info@msif.org

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