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Atlas of MS launched: compare MS data worldwide

On August 14, 2006, MSIF launched the Atlas of MS. For the first time, data about the epidemiology of MS and the availability of resources for people with MS can be compared worldwide. The results of the MSIF and World Health Organization survey can be analysed and viewed at country, regional, and global levels for 64 countries on the Atlas of MS website, www.atlasofms.org

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Global Good Practice project meeting

MSIF is developing a database of successful MSIF member society projects based on the Principles to Promote the Quality of Life of People with MS (QoL Principles). On Friday, 11 August 2006 the Work Group tasked with developing the project to share good practice met by teleconference call to discuss next steps.

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Justice for unfairly dismissed woman with MS

source: UK MS Society

A UK woman has won a tribunal case against her employer after being unfairly dismissed due to memory lapses and fatigue caused by multiple sclerosis.

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Profile of the Month : January 2008

Yasmine Rwanyindo

Country: Rwanda
Age: 38
Year of diagnosis: August 2003
Occupation: Administrative and financial manager for a project

English Spanish Italian Russian French German

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Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

Activation of transcription factor NF-kappaB in the central nervous system (CNS) has been linked to autoimmune demyelinating disease. This study demonstrates that NF-kappaB-dependent gene expression in non-microglial cells of the CNS provides a permissive proinflammatory milieu that is critical for CNS inflammation and tissue damage in autoimmune demyelinating disease.

authors: van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M.

source: Nat Immunol. 2006 Aug 6; [Epub ahead of print]

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Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes

This study provides strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies.

authors: Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R.

source: J Neurosci. 2006 Aug 2;26(31):8206-16.

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Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis

The lower expression Fas, a cytochine receptor, in activated T cells might contribute to disease pathogenesis by prolonging cell survival and favouring their migration into the central nervous system.

authors: Julia E, Montalban X, Al-Zayat H, Issazadeh-Navikas S, Goertsches R, Martin R, Comabella M.

source: J Neuroimmunol. 2006 Aug 7; [Epub ahead of print]

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Higher sensitivity in the detection of inflammatory brain lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis using high field MRI: an intraindividual comparison of 1.5 T with 3.0 T.

This study demonstrates that high-field MRI at 3.0 T provides a significantly higher detection rate of inflammatory brain lesions especially in the infratentorial, juxtacortical and periventricular anatomic region.

authors: Wattjes MP, Lutterbey GG, Harzheim M, Gieseke J, Traber F, Klotz L, Klockgether T, Schild HH.

source: Eur Radiol. 2006 Sep;16(9):2067-2073. Epub 2006 Apr 29.

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8th International Congress of Neuroimmunology, October 2006

source: International Congress of Neuroimmunology

The 8th International Congress of Neuroimmunology will take place on October 15-19, 2006 in Nagoya, Japan.

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UK organisations join forces to call for prescription charges reform

source: UK MS Society

Nine key patient organisations, including the UK MS Society, have joined forces to lobby the UK government to review the current prescription charges system in the country.

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