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Making Connections
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| Summaries of new MSIF activities, events, projects, programmes, resources, publications and more. |
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People with MS News
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Summaries of news, views and achievements from people with MS around the world.
Have you (or has someone you know with MS) achieved something that may be an inspiration to others? If so, please contact Lucy Hurst and ask about being Profile of the Month on our website. |
Profile of the Month : January 2008
Gerardo Garcia Perales
Home: Madrid, Spain
Age: 42
Diagnosis: 1986
Occupation: Madrid MS Society President, and Spain MS Society Treasurer
English Espanol Francais Russian Italian German
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Research News
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| Summaries of all the latest research findings on MS selected by a team based at the Institute of Neurology, London. |
Imaging of CNS myelin by positron-emission tomography
In this study the authors provide evidence that (11)C-radiolabeled BMB, a synthesized fluorescent molecule, that binds selectively to myelin both ex vivo and in vivo, can be used in vivo to image central nervous system myelin by positron-emission tomography in baboon. These results provide a perspective for developing a brain myelin imaging technique by positron-emission tomography.
authors: Stankoff B, Wang Y, Bottlaender M, Aigrot MS, Dolle F, Wu C, Feinstein D, Huang GF, Semah F, Mathis CA, Klunk W, Gould RM, Lubetzki C, Zalc B.
source: Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9304-9. Epub 2006 Jun 5.
read more
Regenerative and immunomodulatory potential of mesenchymal stem cells.
In this paper the authors discuss mesenchymal stem cells (MSCs) highlighting their potential for regenerative and immunoregulatory cell therapy. MSCs appear to be a very promising tool also for MS.
authors: Krampera M, Pasini A, Pizzolo G, Cosmi L, Romagnani S, Annunziato F.
source: Curr Opin Pharmacol. 2006 Jun 12; [Epub ahead of print]
read more
Antibiotic use and risk of multiple sclerosis.
Some reports suggest that bacteria, including Chlamydophila pneumoniae, could be involved in the etiology of multiple sclerosis. The authors hypothesize that if true, persons who used antibiotics active against these bacteria, compared with nonusers, might be at lower risk of multiple sclerosis. However this study shows that use of antibiotics active against C. pneumoniae is not associated with a decreased risk of short-term multiple sclerosis.
authors: Alonso A, Jick SS, Jick H, Hernan MA.
source: Am J Epidemiol. 2006 Jun 1;163(11):997-1002. Epub 2006 Apr 5.
read more
Potassium channel blockers in multiple sclerosis: Neuronal K(v) channels and effects of symptomatic treatment.
This paper is a review of the current status of basic science and clinical research related to the therapeutic targeting of voltage-gated K(+) channels (K(v)) in MS. Covered are (1) K(v) channel nomenclature, structure, function, and pharmacology; (2) classic and current experimental morphology and neurophysiology studies of demyelination and conduction deficits; and (3) a comprehensive overview of clinical trials utilizing 4-AP and 3,4-DAP in MS patients.
authors: Judge SI, Bever CT Jr
source: Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9.
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MS News
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| Summaries of MS news from websites around the world. |
Novel Oral Therapy Suppresses Immune Attack in MS Model
source: US National MS Society
Researchers report success in treating a mouse model of multiple sclerosis with a novel oral treatment. This strategy has shown effectiveness in treating humans with similar diseases via intravenous administration. Hirofumi Ochi, MD, PhD, Howard L Weiner, MD (Harvard’s Brigham and Women's Hospital, Boston) and colleagues present this study in Nature Medicine (2006 May 21; [Epub ahead of print]).
read more
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Multiple Sclerosis International Federation
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