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Du Pré Fellowship winner Marcelo Matiello reports to the MSIF Board

MSIF's 2005 Du Pré Fellowship recipient, Brazilian Marcelo Matiello, presented a report about his research project at the Mayo Clinic in Rochester, US, to the MSIF Board at its recent meeting in Washington DC.

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Profile of the Month : January 2008

Meg Kingston

Country: Wales
Age: 40-something
Year of diagnosis: late 1990s
Occupation: writer and former IT consultant

English Italiano Deutsh Espanol Francais Russian

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Effect of corpus callosum damage on ipsilateral motor activation in patients with multiple sclerosis: A functional and anatomical study

This study uses fMRI to show that there is damage to inhibitory pathways in the brain in MS which may account for some of the increased activation on MRI when motor tasks are performed

authors: Lenzi D, Conte A, Mainero C, Frasca V, Fubelli F, Totaro P, Caramia F, Inghilleri M, Pozzilli C, Pantano P.

source: Hum Brain Mapp. 2006 Nov 1; [Epub ahead of print]

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CRYAB promoter polymorphisms: Influence on multiple sclerosis susceptibility and clinical presentation

This study explores the role of polymorphisms in the CRYAB gene in the pathogenesis of MS. They may increase susceptibility to MS by modulating the immune response, and the authors conclude that they should be included in further biomarker studies.

authors: Stoevring B, Frederiksen JL, Christiansen M.

source: Clin Chim Acta. 2007 Jan;375(1-2):57-62. Epub 2006 Jun 20

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Simvastatin regulates oligodendroglial process dynamics and survival

This study explores the cellular effects of Simvastatin, which is being evaluated as a potential therapy in MS.

authors: Miron VE, Rajasekharan S, Jarjour AA, Zamvil SS, Kennedy TE, Antel JP.

source: Glia. 2006 Oct 31; [Epub ahead of print]

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Does the scoring of late responses affect the outcome of the paced auditory serial addition task (PASAT)?

This study emphasises the importance of clearly stating scoring methods when using the PASAT test, a measure of cognitive function, in research studies.

authors: Balzano J, Chiaravalloti N, Lengenfelder J, Moore N, Deluca J.

source: Arch Clin Neuropsychol. 2006 Oct 24; [Epub ahead of print]

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Effect of intrathecal baclofen on sleep and respiratory function in patients with spasticity

This study on intra-thecal baclofen (a centrally acting muscle relaxant which is administered directly into the spinal fluid to treat spasticity) showed that patients had improved sleep, but that their ability to breath normally overnight was not affected. The authors conclude that this may indicate that the drug acts directly on the spinal nerves, and does not affect the brain.

authors: Bensmail D, Quera Salva MA, Roche N, Benyahia S, Bohic M, Denys P, Bussel B, Lofaso F.

source: Neurology. 2006 Oct 24;67(8):1432-6.

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Chronotherapy using Corticosteroids for Multiple Sclerosis Relapses

This study explores the effect of giving steroids to treat acute MS relapses at times that are tailored to the bodies natural rhythms, as the immune system alters at different times of the day and night. The authors conclude that nighttime administration of steroids may be preferable to patients.

authors: Glass-Marmor L, Paperna T, Ben-Yosef Y, Miller A.

source: J Neurol Neurosurg Psychiatry. 2006 Oct 20; [Epub ahead of print]

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Canadian study finds MS increasing among women

source: MS Society of Canada

Researchers using a Canada-wide database have found that multiple sclerosis in women has approximately tripled over the past 60 years and that the female to male sex ratio now exceeds three women with MS for every one man (3.5:1).

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Abnormal liver test results found in people with multiple sclerosis in placebo arms of clinical trials

source: MS Society of Canada

Researchers at the University of British Columbia, Canada, report people with MS or clinically isolated syndrome (CIS) who were in the placebo (non-treated) groups of clinical trials have greater than expected abnormal liver test results.

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Recent news from New Zealand MS Society

source: New Zealand MS Society

The latest roundup of recent news from the New Zealand MS Society is now available.

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Three new UK MS Society booklets published

source: UK MS Society

The UK MS Society has published three new issues in the MS Essentials range of booklets for people affected by MS.

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