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Madrid06 conference - still places left!

There are still some places left at the international conference on September 26 in Madrid, taking place just prior to ECTRIMS. The Madrid06 conference, titled "Research in MS: from basic science to quality of life", is aimed at people affected by MS, health professionals and MS society staff and volunteers.

Leading international MS specialists will present the current developments in MS research in an accessible, less scientific format.

For more details, please click here

Have you visited MSIF's Atlas of MS website?

After one month, more than 10,000 data queries have been run on the Atlas of MS website by 3,000 people from 90 countries around the world.

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Take part in our online survey

The next edition of MS in focus looks at caregiving and MS. To help inform this edition of the magazine, please take part in our online survey.

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MSIF's poster presentation at ECTRIMS

We are delighted that an abstract about the Atlas of MS publication, a collaborative project between MSIF and the World Health Organization, will be presented as a poster at next week's Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS).

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Profile of the Month : January 2008

Satu Salonen

Country: Finland
Age: 55
Year of diagnosis: 1999
Occupation: Former company director, then pensioner and now author

English Spanish Italian French Russian German

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Patient information on cognitive symptoms in multiple sclerosis - acceptability in relation to disease duration

This study investigated the acceptability of information on cognitive assessments to patients with MS, and found it to be acceptable and appropriate.

authors: Heesen C, Segal J, Reich C, Hamalainen P, Broemel F, Niemann S, Simon U, Gross R, Kasper J.

source: Acta Neurol Scand. 2006 Oct;114(4):268-72

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Successful treatment with intradetrusor botulinum-a toxin for urethral urinary leakage (catheter bypassing) in patients with end-staged multiple sclerosis and indwelling suprapubic catheters

This report on three patients with bypassing suprapubic catheters found that intra-detrusor botulinum toxin injection is a useful intervention to prevent leakage.

authors: Lekka E, Lee LK.

source: Eur Urol. 2006 Oct;50(4):806-10. Epub 2006 Jan 6

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Progressive resistance exercise for people with multiple sclerosis

This study investigated the impact of a progressive resistance exercise programme performed twice weekly over ten weeks on nine MS patients. There was a significant improvement in arm strength, leg endurance, and fast walking speed in the subjects, who also felt that the influence of MS in determining their physical function was decreased.

authors: Taylor NF, Dodd KJ, Prasad D, Denisenko S.

source: Disabil Rehabil. 2006 Sep 30;28(18):1119-26

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Oral fingolimod (FTY720) for relapsing multiple sclerosis

This study tested Fingolimod, an oral immunomodulator, against placebo to reduce disease activity in 281 patients with RRMS, as measured by a reduction in gadolinium-enhancing lesions on MRI. Over a six month period and twelve month extension, the Fingolimod-treated groups had lower relapse rates and less gadolinium enhancement on MRI. There were a variety of adverse events associated with the treatment, including one case of encephalopathy.

authors: Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, Haas T, Korn AA, Karlsson G, Radue EW.

source: N Engl J Med. 2006 Sep 14;355(11):1124-40.

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Are initial demyelinating event recovery and time to second event under differential control?

This study sought to find clinical predictors for how much patients recover from an initial demyelinating event, and for how long the period was until a second demyelinating event. In the 186 patients studied, more severe onset and polyregional presentation predicted a less complete recovery from a first event, and non-white ethnicity and age below 30 years predicted a higher risk of a second attack over the one year study period. The authors suggest that having distinct predictors for the two outcomes may indicate that recovery and time to second event are under separate biologic control.

authors: West T, Wyatt M, High A, Bostrom A, Waubant E.

source: Neurology. 2006 Sep 12;67(5):809-13.

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Relapses and subsequent worsening of disability in relapsing-remitting multiple sclerosis

This study investigated whether relapses contribute to the development of sustained disability in patients with RRMS, using data from 256 patients. The results showed no consistent evidence that relapses which occurred during the study period of ~2.5 years caused a sustained increase in EDSS (a clinical scale used to measure disability) over this period.

authors: Young PJ, Lederer C, Eder K, Daumer M, Neiss A, Polman C, Kappos L

source: Neurology. 2006 Sep 12;67(5):804-8.

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Oral Fingolimod reduces MS disease activity - larger, Phase 3 study underway

source: US National MS Society

In a Phase 2 controlled clinical trial involving 255 people with active, relapsing multiple sclerosis, oral fingolimod significantly reduced signs of inflammation on MRI scans.

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The Queen's Nursing Institute/UK Multiple Sclerosis Society award

source: UK MS Society

The QNI offers a number of different awards schemes that give funding and support for practice-based or research projects, as well as an award to recognise outstanding service in the field of community nursing.

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Transmission of MS to children: study finds men transmit MS more often to their children than do women

source: MS Society of Canada

A new study shows that, in a group of 441 children with a parent with multiple sclerosis, fathers with MS were more likely to pass on the disease to children than mothers with MS.

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