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Sign up now for MS in focus on pain and receive a free folder to store your magazines!

Issue 10 of MS in focus, which looks at pain and MS, will shortly be published. If you haven't already signed up please do so here before 27 June to receive your free printed copy, along with a free folder which is designed to store the ten issues of the magazine published so far.

The pain edition of the magazine will also soon be available for free download from the publications page of our website and older printed issues can be ordered for free by emailing a request to info@msif.org.

Two of the "How To" series now in Latin American Spanish

We are delighted that two publications from our How To series have been translated into Latin American Spanish and are now available to download from our website.

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Profile of the Month : January 2008

Wendy Temple

Age: 49
Country: Australia
Occupation: Teacher
Year of diagnosis: 2003

"That would be my advice to anyone who has MS – there is always tomorrow. If you can’t do it today, try again tomorrow."

English Italiano Espanol Deutsch Francais Russian

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High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord

The authors studied a new MRI technique in animal models of MS. They found it to be more useful than traditional MRI in detecting neural damage.

authors: Deboy CA, Zhang J, Dike S, Shats I, Jones M, Reich DS, Mori S, Nguyen T, Rothstein B, Miller RH, Griffin JT, Kerr DA, Calabresi PA.

source: Brain. 2007 Jun 8

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Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years. A case control study.

The authors followed up a group of people with MS with MRI scans over five years. They found that different brain tissue compartments showed different patterns of volume change over time.

authors: Horakova D, Cox JL, Havrdova E, Hussein S, Dolezal O, Cookfair D, Dwyer MG, Seidl Z, Bergsland N, Vaneckova M, Zivadinov R.

source: J Neurol Neurosurg Psychiatry. 2007 Jun 5

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CD44 variant DNA vaccination with virtual lymph node ameliorates experimental autoimmune encephalomyelitis through the induction of apoptosis

The authors looked at the effects of a DNA vaccination technique, aiming to reduce the pathological response of the immune system in an animal model of MS. They found it to be effective in reducing the number of brain lesions in mice.

authors: Garin T, Rubinstein A, Grigoriadis N, Nedvetzki S, Abramsky O, Mizrachi-Koll R, Hand C, Naor D, Karussis D.

source: J Neurol Sci. 2007 Jul 15;258(1-2):17-26.

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Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination

The authors studied alphaB-crystallin, a molecule that works as a brake on the pathological responses of the immune system, and that could have a protective and therapeutic role in people with MS. They have found that this molecule was able to ameliorate EAE, the animal model of MS.

authors: Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'conner K, Hafler DA, Sobel RA, Robinson WH, Steinman L.

source: Nature. 2007 Jun 13

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Predicting short-term disability in multiple sclerosis

The authors looked at MRI predictors of short-term disability in a group of people with MS. They found that reduced brain volume and higher lesion volume correlated with a higher disability.

authors: Gauthier SA, Mandel M, Guttmann CR, Glanz BI, Khoury SJ, Betensky RA, Weiner HL.

source: Neurology. 2007 Jun 12;68(24):2059-65

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Possible target of immune attack in MS and new therapeutic approach identified by US National MS Society-sponsored investigators

source: US National MS Society

A new study by US National MS Society-supported researchers suggests a small protein (alpha B-crystallin) normally produced by cells to protect against injury may itself be the target of the multiple sclerosis immune attack.

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Lecture on cognitive problems in MS at MS Iceland meeting

source: MS-félag Íslands

Dr Bjorn Sperling will give a lecture (in English) on cognitive problems that might occur in MS during a meeting of the MS Society of Iceland. The meeting will take place today, 19 June, at 18.30 and will be webcast on MS-félag Íslands website.

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Call for equal access to MS therapy and care

source: EMSP

The EMSP Conference in Brussels (29-30 May) called for equal access to therapy and care throughout Europe and launched the “Multiple Sclerosis Information Dividend” project.

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New edition of Spanish MS Society magazine published

source: FELEM

Edition 15 of Federación Española para la Lucha contra la EM’s (FELEM) biannual magazine Temas is now available to download (in Spanish).

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Enrolment begins for US study of MBP8298 in secondary-progressive MS

source: US National MS Society

Enrolment has begun for a study testing the safety and effectiveness of the experimental drug MBP8298 (BioMS Medical Corp.) in 510 people with secondary-progressive MS. Up to 60 sites across the US will be enrolling patients by September.

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ICF Core Sets for MS survey

source: ICF Research

Are you a health professional with a minimum of five years experience in the treatment of people with MS? Would you consider completing a short 5-question online survey as part of a project to develop International Classification of Functioning, Disability and Health (ICF) Core Sets for MS?

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