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Sign the petition for the Ratification of the UN Convention on the Rights of Persons with Disabilities

If you haven't already, please sign MSIF's petition for the Ratification of the UN Convention on the Rights of Persons with Disabilities.

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Profile of the Month : January 2008

Jaroslav Zika
Country: Czech Republic
Occupation: Retired Engineer
Year of diagnosis: 1987
Type of MS: PPMS

"I realise I lost my job and mobility to MS, but on the other hand I have learned things I would otherwise never have found out"

English Italian Russian German French Spanish Czech

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Migration and multiple sclerosis: The French West Indies experience

This study investigates the incidence of MS in the French west Indies, which has seen a dramatic rise in the condition since large numbers of its population returned from living in France. The authors postulate reduced exposure to sunlight and intestinal parasites as possible reasons.

authors: Cabre P.

source: J Neurol Sci. 2007 Nov 15;262(1-2):117-21. Epub 2007 Jul 24.

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Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?

This post-mortem study comparing human brain lesions to those in a rat model of MS, found that innate immune cells are active early on in lesion development, before infiltration of the lesion by T-cells (part of the cell-mediated immune process).

authors: Marik C, Felts PA, Bauer J, Lassmann H, Smith KJ.

source: Brain. 2007 Nov;130(Pt 11):2800-15. Links

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Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitis

This study in a mouse model of MS again demonstrates the role of the innate immune cells, this time in grey matter lesions, which have been linked to clinical progression in MS. The study suggests that microglial activation persists through the chronic disease phase, while peak T cell responses are known to be associated with acute inflammation.

authors: Rasmussen S, Wang Y, Kivisäkk P, Bronson RT, Meyer M, Imitola J, Khoury SJ.

source: Brain. 2007 Nov;130(Pt 11):2816-29. Epub 2007 Sep 22.

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Mitoxantrone treatment in multiple sclerosis: a 5-year clinical and MRI follow-up

In this study of 50 patients with severe RRMS treated with mitoxantrone, one third of patients continued to progress during treatment, although during the follow-up period this number decreased. The patients progressed despite there being no active lesions on their MRI scans. Ten per cent of patients withdrew from treatment due to side effects.

authors: Buttinelli C, Clemenzi A, Borriello G, Denaro F, Pozzilli C, Fieschi C.

source: Eur J Neurol. 2007 Nov;14(11):1281-1287.Links

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New Zealand: 40 years of MSSNZ

While MSIF was celebrating its 40th anniversary in Prague, in New Zealand that same week, the Multiple Sclerosis Society of New Zealand (MSSNZ) was marking its own important 40th anniversary milestone.

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France: 2008 €100,000 Scientific Award for MS research from Institut de France

La Fondation NRJ was created in May 1999 to promote medical research, particularly in the neurosciences.

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India: MSSI’s Diwali celebrations

On 27 October MSSI (Multiple Sclerosis Society of India) participated in the Diwali Mela at the Italian Embassy, Chanakyapuri. The Mela was a huge success and the MSSI stall sold many lovely things made and contributed by its members Parul, Uma Bhatia, Rani, Anjum, Renuka and Nina, building great awareness for the cause.

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