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Munich: International Classification of Functioning, Disability and Health (ICF) core sets for MS

The German ICF Research Branch (DIMDI) of the World Health Organization (WHO) Collaborating Centre for the Family of International Classifications has released its first newsletter, designed to inform readers regularly of new projects and progress on 12 chronic conditions, including MS.

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Profile of the Month : June 2008

Christo Balabanov
Country: Bulgaria
Age: 49
Profession: Mechanical engineer
Type of MS: Secondary progressive
Year of diagnosis: 1991

How Multiple Sclerosis changed my life
(What I gained and lost from MS)

English Italiano Francais Espanol Russian Deutsche

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Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis.

The authors found some differences in the function of immune cells between people with and without MS that may play a role in the pathogenesis of MS.

authors: Zhang X, Tang Y, Sujkowska D, Wang J, Ramgolam V, Sospedra M, Adams J, Martin R, Pinilla C, Markovic-Plese S.

source: Eur J Immunol. 2008 Apr 15 [Epub ahead of print]

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The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study.

Iron imbalance has been associated with inflammation. The authors investigated the role of iron metabolism in MS and concluded that iron overload and upregulation of iron-handling proteins can contribute to the pathogenesis of MS.

authors: Abo-Krysha N, Rashed L.

source: Mult Scler. 2008 Apr 11 [Epub ahead of print]

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Gene expression analysis of interferon-{beta} treatment in multiple sclerosis.

The authors found that IFN-beta induced the expression of a large number of genes at the beginning of treatment. Additional studies are needed to clarify which changes in gene expression can account for the immunomodulatory and clinical effects of treatment with IFN-beta.

authors: Sellebjerg F, Datta P, Larsen J, Rieneck K, Alsing I, Oturai A, Svejgaard A, Soelberg Sørensen P, Ryder LP.

source: Mult Scler. 2008 Apr 11 [Epub ahead of print]

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Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve.

The authors investigated the role of Oligodendrocyte-specific protein in the development of experimental autoimmune encephalomyelitis, the animal model of MS. They found that this protein caused selective demyelination of the optic nerve in rhesus monkeys.

authors: Bajramovic JJ, Brok HP, Ouwerling B, Jagessar SA, van Straalen L, Kondova I, Bauer J, Amor S, Hart BA, Ben-Nun A.

source: Eur J Immunol. 2008 Apr 15 [Epub ahead of print]

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(1)H MR spectroscopy of inflammation, infection and ischemia of the brain.

This review is about spectroscopy, a relatively new radiological technique, which looks for the metabolic components of tissues and can be useful to improve our knowledge of MS pathogenesis.

authors: Mader I, Rauer S, Gall P, Klose U.

source: Eur J Radiol. 2008 Apr 11 [Epub ahead of print]

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Global Dinner Party 2008 in Second Life: update

The Global Dinner Party (GDP) 2008 success stories are still coming in, and we now have an update on the only (that we know of!) virtual GDP, held in Second Life (SL).

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Romania: project to improve the lives of young people with MS

The Romanian MS society is implementing a resolution in collaboration with the European Youth Parliament Romania to the Committee on Social Affairs and Equal Opportunities, designed to help young people with MS. Vladimír Spidla, European Commissioner for Employment, Social Affairs and Equal Opportunities commented, “People with disabilities must become active players in the internal market. It needs to become a reality for all, including people with disabilities. Accessibility to goods, services and infrastructures are a precondition for full enjoyment of fundamental rights of people with disabilities.”

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