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Profile of the Month : September 2008

Jim Wolfgang

Country: Canada
Age: 75
Occupation: Retired Union Representative
Type of MS: Primary progressive
Year of diagnosis: 1976

I have seen many positive changes in the way governments at every level in Canada have responded to people with MS; however, we still have a long way to go.

Read the full article here:

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Cannabis use in Spanish patients with multiple sclerosis: Fulfillment of patients' expectations?

In this cross-sectional study the authors investigated the use of cannabis in people with MS. They found that the use of cannabis for medicinal purposes was high among people with MS, although clinical improvement was reported by only half of them.

authors: Martínez-Rodríguez JE, Munteis E, Carreño M, Blanco Y, Roquer J, Abanades S, Graus F, Saiz A.

source: J Neurol Sci. 2008 Aug 6.

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Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

In multiple sclerosis, genes play a role and those related to the inflammatory response may be especially important. The authors of this study found that some specific genes involved in the immune response might be involved in the development of a second relapse of MS.

authors: Corvol JC, Pelletier D, Henry RG, Caillier SJ, Wang J, Pappas D, Casazza S, Okuda DT, Hauser SL, Oksenberg JR, Baranzini SE.

source: Proc Natl Acad Sci U S A. 2008 Aug 8

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Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis

In MS, there is a certain level of change in the part of the brain that is not affected, to compensate for damage. The authors of this study have demonstrated that people with MS may have compensatory changes in the peripheral nervous system as well as the brain.

authors: Ng K, Howells J, Pollard JD, Burke D.

source: Brain. 2008 Aug 12

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Will Rogers phenomenon in multiple sclerosis

Changes in the diagnostic criteria have allowed a diagnosis of MS in patients with a single relapse. The authors warn that these patients should not be grouped with patients diagnosed according to the old criteria in clinical trials, because they represent a different group with potentially different characteristics.

authors: Sormani MP, Tintorè M, Rovaris M, Rovira A, Vidal X, Bruzzi P, Filippi M, Montalban X.

source: Ann Neurol. 2008 Aug 7

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Interleukin-10 and Interleukin-12 Modulation in Patients with Relapsing-Remitting Multiple Sclerosis on Therapy with Interferon-beta 1a: Differences in Responders and Non Responders

The authors of this study found that in people with MS who respond well to interferon, there are specific changes in proteins involved in the immune response. They propose that these changes could be used as predictors of a good response to the drug.

authors: Carrieri PB, Ladogana P, Di Spigna G, Fulvia de Leva M, Petracca M, Montella S, Buonavolonta L, Florio C, Postiglione L.

source: Immunopharmacol Immunotoxicol. 2008 Aug 4:1-9.

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US society-funded researchers find pattern of gene activity associated with high risk for MS

source: US National MS Society

In a major step towards discovering molecules that may be used as “markers” to predict MS disease activity and progression, researchers identified a pattern of gene expression within immune cells that was associated with quick conversion to MS in a study of 37 people with a first event suggestive of MS.

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Canadian clinical trial research survey

source: University of Victoria, Canada

PhD students at the University of Victoria, Canada, are looking for people to take part in an online survey about how people search for clinical trials data.

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Data centre chosen to foster research by US National MS Society Pediatric Centers of Excellence

source: US National MS Society

The network of Pediatric Centers of Excellence established by the US National MS Society has chosen the Collaborative Studies Coordinating Center at the University of North Carolina to coordinate and expedite its efforts to investigate MS in children.

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