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Countdown to The MS Global Dinner Party – 23 February 2008

Across the globe national MS societies, associations and organisations are putting the final touches to their Global Dinner Party events.

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2007 Evelyn Nicholson Winner update

In 2007, Susana Caballido Perdigón from Uruguay used her Evelyn Nicholson Award to visit the MS Society of Argentina. Find out how Susana got on and how the award raised awareness of MS in Uruguay.

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Profile of the Month : April 2008

Name: Caitlin Kernaghan
Country: Canada
Age: 11
Year of diagnosis: 2005

"I tell my story to other people because I HOPE they would like to donate for research so that we can find a cure and that no other kids or adults will have to spend their whole life with MS."

English German French Italian Spanish

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Corticosteroids for the long-term treatment in multiple sclerosis.

This review summarises findings from studies done on the role of steroids in the long term management of MS. It concludes that there is not enough evidence to suggest that steroids are useful in delaying progression to long term disability.

authors: Ciccone A, Beretta S, Brusaferri F, Galea I, Protti A, Spreafico C.

source: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD006264.

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Homogeneity of active demyelinating lesions in established multiple sclerosis.

This post mortem study on 27 subjects with MS demonstrated a uniformity of immunopathological findings in brain lesions across subjects. To some extent this argues against a previous hypothesis that there are four separate immunopathological lesion types, with individual patients exhibiting only one type of lesion.

authors: Breij EC, Brink BP, Veerhuis R, van den Berg C, Vloet R, Yan R, Dijkstra CD, van der Valk P, Bö L.

source: Ann Neurol. 2008 Jan;63(1):16-25.

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Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis.

This study follows patients who presented with a single episode suggestive of an MS relapse twenty years ago. It suggests that MRI scans done at presentation and in the first few years afterwards may help to predict clinical course.

authors: Fisniku LK, Brex PA, Altmann DR, Miszkiel KA, Benton CE, Lanyon R, Thompson AJ, Miller DH.

source: Brain. 2008 Jan 29 [Epub ahead of print]

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Botulinum Toxin A Detrusor Injections in Patients with Neurogenic Detrusor Overactivity Significantly Decrease the Incidence of Symptomatic Urinary Tract Infections.

This study in 30 patients with bladder problems common in MS suggests that injection of Botulinum toxin into the bladder muscle helps to reduce the frequency of urinary tract infections, probably secondary to an improvement in bladder function.

authors: Gamé X, Castel-Lacanal E, Bentaleb Y, Thiry-Escudié I, De Boissezon X, Malavaud B, Marque P, Rischmann P.

source: Eur Urol. 2008 Mar;53(3):613-619. Epub 2007 Aug 28

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Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition.

This study from several European centres examines control of hand movements in 56 people with MS using functional MRI. The authors conclude that in MS there is impairment of mechanisms which inhibit nerve function, and this may reduce movement control.

authors: Manson SC, Wegner C, Filippi M, Barkhof F, Beckmann C, Ciccarelli O, De Stefano N, Enzinger C, Fazekas F, Agosta F, Gass A, Hirsch J, Johansen-Berg H, Kappos L, Korteweg T, Polman C, Mancini L, Manfredonia F, Marino S, Miller DH, Montalban X, Palace J, Rocca M, Ropele S, Rovira A, Smith S, Thompson A, Thornton J, Yousry T, Frank JA, Matthews PM.

source: Exp Brain Res. 2008 Jan 31 [Epub ahead of print]

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US: The ‘Moving Forward’ films available to view online

The ‘Moving Forward’ films from the US National MS Society (NMSS) National Conference in October 2007 are now available to view on YouTube.

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