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Professor Alan Thompson appointed as Director of the Institute of Neurology, London

We are delighted to announce that Professor Alan Thompson has been appointed to the position of Director of the Institute of Neurology. He will take up his new role from 1 April 2008.

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2007 Du Pré Grant recipients update: Maria Katsara

Maria was studying for a PhD at the University of Patras, Greece, and used her £4000 Du Pré Grant to extend her visit to the Immunology and Vaccine Laboratory, Austin Research Institute, Burnet Institute in Australia by a further six months.

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Country: Uruguay
Age: 33
Profession: Assistant Professor in Imunohistochemistry, Cytology and Biochemistry, Faculty of Veterinary Sciences
Year of diagnosis: 2003
Type of MS: Relapse remitting

"Everything leaves its imprint and makes us who we are today"

English Francais Deutsche Español Русско Italiano

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Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

In this interesting paper, the authors looked at the different pathological patterns of MS lesion in post-mortem specimens. They identified proteins that were present in each of the different types. Many of the proteins were of unknown function, but some present in chronic active plaques were known to be involved in coagulation and inflammation pathways. They inhibited these proteins in the mouse model of MS with clinical benefit. The authors suggest that this is a good way of identifying new targets for potential treatment in MS.

authors: Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L.

source: Nature. 2008 Feb 28;451(7182):1076-81. Epub 2008 Feb 17

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Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement.

The authors describe a new technique of demonstrating inflammation on MRI scans. This may help to define more clearly the different patterns of inflammation which are seen in individual patients, including perhaps which areas will be repaired.

authors: Vellinga MM, Oude Engberink RD, Seewann A, Pouwels PJ, Wattjes MP, van der Pol SM, Pering C, Polman CH, de Vries HE, Geurts JJ, Barkhof F.

source: Brain. 2008 Mar;131(Pt 3):800-7. Epub 2008 Feb 1.

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Cognitive impairment in different MS subtypes and clinically isolated syndromes.

The authors studied changes in information processing in people with the different subtypes of MS. Understanding what stage this occurs at, and what processes it impacts upon, might make it possible to treat this aspect of the condition better in future.

authors: Potagas C, Giogkaraki E, Koutsis G, Mandellos D, Tsirempolou E, Sfagos C, Vassilopoulos D.

source: J Neurol Sci. 2008 Apr 15;267(1-2):100-6. Epub 2007 Nov 13.

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A 3-year longitudinal study of cognitive impairment in patients with primary progressive multiple sclerosis: Speed matters.

This study looked at information-processing in patients with the primary progressive type of MS. They found that the condition primarily affects the speed at which this can be performed.

authors: Denney DR, Lynch SG, Parmenter BA.

source: J Neurol Sci. 2008 Apr 15;267(1-2):129-36. Epub 2007 Oct 31.

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Malaysia: report on motivational workshop for persons with MS and caregivers

The Malaysian MS society held a talk and workshop on personal motivation and overcoming daily difficulties for persons with MS and caregivers on 1 March 2008.

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