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MSIF News
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Making Connections
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| Summaries of new MSIF activities, events, projects, programmes, resources, publications and more. |
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Profile of the Month
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| Summaries of news, views and achievements from people with MS around the world. |
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Research News
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| Summaries of all the latest research findings on MS selected by a team based at the Institute of Neurology, London. |
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
The role of genes in the pathogenesis of MS is complex. The authors found an association with a gene involved in damage of the nerves rather than the myelin sheath.
authors: Aulchenko YS, Hoppenbrouwers IA, Ramagopalan SV, Broer L, Jafari N, Hillert J, Link J, Lundström W, Greiner E, Dessa Sadovnick A, Goossens D, Broeckhoven CV, Del-Favero J, Ebers GC, Oostra BA, van Duijn CM, Hintzen RQ
source: Nat Genet. 2008 Nov 9. [Epub ahead of print]
read more
Heterogeneity in response to interferon beta in patients with multiple sclerosis: a 3-year monthly imaging study
It is known that beta-interferon reduces relapses by a third. The authors investigated the effect that it has on reducing inflammation on MRI in people with MS. They found that MRI activity was actually reduced by a half.
authors: Chiu AW, Richert N, Ehrmantraut M, Ohayon J, Gupta S, Bomboi G, Gaindh D, Cantor FK, Frank JA, McFarland HF, Bagnato F
source: Arch Neurol. 2008 Nov 10. [Epub ahead of print]
read more
Pregnancy and multiple sclerosis
This article reviews the main issues related to pregnancy in MS, concluding that in most people there are no special risks.
authors: Lee M, O'Brien P
source: J Neurol Neurosurg Psychiatry. 2008 Dec;79(12):1308-11
read more
The effects of interferon beta-1a on proton MR spectroscopic imaging in patients with multiple sclerosis, a controlled study, preliminary results
The authors used spectroscopy, an MRI technique, to assess the effect of beta-interferon on brain inflammation in people with MS. They found some differences after starting treatment, suggesting benefits on brain metabolism.
authors: Toprak MK, Cakir B, Ulu EM, Arat Z, Benli US, Can U, Ağildere M
source: Int J Neurosci. 2008 Dec;118(12):1645-58
read more
Sample sizes for brain atrophy outcomes in trials for secondary progressive multiple sclerosis
Brain volume on MRI is an important outcome measure when testing new treatments. In this technical paper, the authors studied the number of people with secondary progressive MS who would need to be enrolled in a trial, in order to show a treatment effect.
authors: Altmann DR, Jasperse B, Barkhof F, Beckmann K, Filippi M, Kappos LD, Molyneux P, Polman CH, Pozzilli C, Thompson AJ, Wagner K, Yousry TA, Miller DH
source: Neurology. 2008 Nov 12. [Epub ahead of print]
read more
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Multiple Sclerosis International Federation
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