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Making Connections
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MSIF News
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| Summaries of new MSIF activities, events, projects, programmes, resources, publications and more. |
MS societies learn more about Fast Forward
source: MSIF
At the request of MSIF's Board, interested MS society representatives met to hear details of the US National MS Society’s (NMSS) Fast Forward research initiative at MSIF’s office in London, on 16 July 2009.
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Profile of the Month
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| Summaries of news, views and achievements from people with MS around the world. |
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Research News
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| Summaries of all the latest research findings on MS selected by a team based at the Institute of Neurology, London. |
Effect of a 4-week period of unloaded leg cycling exercise on spasticity in multiple sclerosis
Rehabilitation has been shown to be crucial in MS, especially when there is a certain degree of disability. Studies also suggested that rehabilitation might be important for spasticity management. The authors aimed to investigate the effect of a four-week programme of unloaded leg cycling on the current scales for spasticity, from both objective (clinical examination and neurophysiology) and subjective (people with MS) points of view. They found that, although this four-week exercise programme did not have a positive impact on objective scales, some improvement was observed from the participants’ point of view.
authors: Sosnoff J, Motl RW, Snook EM, Wynn D
source: NeuroRehabilitation. 2009;24(4):327-31
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Smoking and disease progression in multiple sclerosis
Smoking has been associated with a higher risk of developing MS, but its effect on progression of disability once the disease has started is less clear. The progression of disability may be highly variable amongst people with MS and little is known about factors that could affect this progression rate. In this study the authors followed a group of people with relapsing-remitting MS for a mean time of more than three years. They found that people who smoked converted to the progressive phase of the disease earlier than non-smokers and also had faster rates of lesion load increase and brain volume loss.
authors: Healy BC, Ali EN, Guttmann CR, Chitnis T, Glanz BI, Buckle G, Houtchens M, Stazzone L, Moodie J, Berger AM, Duan Y, Bakshi R, Khoury S, Weiner H, Ascherio A
source: Arch Neurol. 2009 Jul;66(7):858-64
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Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients
People without any neurological symptoms can sometimes show brain abnormalities which are highly suggestive of MS, in scans performed for other medical reasons. However, these people cannot be diagnosed with MS, since the diagnosis of MS requires the demonstration of dissemination in time and space of an inflammatory-demyelinating process within the brain and spinal cord, but always after a first clinical episode suggestive of MS. The authors followed a group of people with MRI abnormalities only (with no symptoms) for a mean time of five years. They found that approximately one third of these people finally had symptoms suggestive of MS. Taking into account the known benefit of the early immunomodulatory treatment (after a first clinical episode) for people who have MS, the question on the possible benefit of a very early treatment (before having symptoms) for people who only have MRI abnormalities arose. However, this question needs to be answered by future studies.
authors: Lebrun C, Bensa C, Debouverie M, Wiertlevski S, Brassat D, de Seze J, Rumbach L, Pelletier J, Labauge P, Brochet B, Tourbah A, Clavelou P; Club Francophone de la Sclérose en Plaques. Collaborators (33): Anne O, Audouin B, Borgel F, Brassat, Brochet, Cabre P, Camu W, Clavelou, Coustans M, Debouverie, Defer G, de Seze, Gout O, Grimaud J, Hautecoeur P, Heinzlef O, Labauge, Laplaud D, Lebrun, le Page E, Mekies C, Moreau T, Papeix C, Pelletier, Pittion S, Rumbach, Seeldrayers P, Slassi I, Tourbah, Vermersch P, Vukusic S, Wiertlevski, Zephir H
source: Arch Neurol. 2009 Jul;66(7):841-6
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Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis
It is known that rehabilitation and exercise are important in MS since they seem to improve physical and psychological aspects in people with this disease. However, little is known regarding the improvement that exercise may have on the inflammation and degeneration that can occur in people with MS. The authors aimed to investigate the effects of exercise on the brain and spinal cord of a population of mice with EAE, the animal model of MS. They found that the mice that had exercised not only had better neurological scores than the mice who had not exercised, but also different characteristics from the neuronal connections (synapses) point of view. These results would suggest that exercise might be able to produce beneficial effects in the central nervous system of people with MS.
authors: Rossi S, Furlan R, De Chiara V, Musella A, Lo Giudice T, Mataluni G, Cavasinni F, Cantarella C, Bernardi G, Muzio L, Martorana A, Martino G, Centonze D
source: Neurobiol Dis. 2009 Jul 7
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Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation
Pain and other unpleasant sensory disturbances are relatively common in MS and can have an important impact on the quality of life. These symptoms are generally due to damage in the central nervous system and their treatment is often unsatisfactory. A number of drugs have been used with this purpose but these are not always effective and they are not without side-effects. For these reasons, the management of pain and sensory disturbances in MS can be difficult and very frustrating for people with MS and clinicians. In this study the authors aimed to compare the efficacy of nortryptiline and self-applied transcutaneous electrical nerve stimulation (TENS) in a group of people with MS and pain or sensory disturbances in the arms. They found that both treatments were similarly efficient in reducing these symptoms.
authors: Chitsaz A, Janghorbani M, Shaygannejad V, Ashtari F, Heshmatipour M, Freeman J
source: Clin J Pain. 2009 May;25(4):281-5
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| Summaries of MS news from websites around the world. |
New facial pain drug eases discomfort
source: MS Ireland
The results of a small study suggest that the drug pregabalin (sold as Lyrica) can reduce stabbing facial pain and other symptoms resulting from a condition called trigeminal neuralgia.
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Multiple Sclerosis International Federation
3rd Floor Skyline House, 200 Union Street, SE1 0LX
Tel: +44 (0) 20 7620 1911
Fax: +44 (0) 20 7620 1922
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Email: info@msif.org
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