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49 MS organisations now signed up to World MS Day

Sign up for a copy of MSIF’s 2008 Annual Review

MSIF’s 2008 Annual Review, which includes details of MSIF’s recent activities and achievements, is coming soon.

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Profile of the Month : January 2010

Ahmed Darwish

Country: Egypt
Age: 47
Type of MS: Secondary progressive MS
Year of Diagnosis: 1992

There is a quote by Gandhi that inspires me, "Live as if you were to die tomorrow. Learn as if you were to live forever." I always have that quote in my mind and try to live by it.

Deutsch English Español Français Русский

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The role of the CD58 locus in multiple sclerosis

In this study the authors have investigated the protective role of some variants of a gene which has recently been associated with the risk of MS and with the function of the regulatory T cells.

authors: De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA

source: Proc Natl Acad Sci USA. 2009 Feb 23

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An investigation of susceptibility loci in benign, aggressive and primary progressive multiple sclerosis in Northern Irish population

In this study the authors aimed to investigate whether the presence of certain genetic characteristics could influence the disease outcome in a Northern Irish population for MS. They found not only significant correlations between some known genetic variants and clinical outcome, but also new genes involved in the clinical course of the disease.

authors: Gray O, Abdeen H, McDonnell G, Patterson C, Graham C,   Hawkins S

source: Mult Scler. 2009 Mar;15(3):299-303

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Short-term adaptation to a simple motor task: a physiological process preserved in multiple sclerosis

In this multi-centre study the process of short-term adaptation to a simple motor task was studied in people with MS and healthy controls by means of functional MRI. No differences were found between the two groups which meant that this is a physiological phenomenon which is preserved in MS. This finding may be very useful for the interpretation of further studies where populations of people with MS and healthy controls are compared.

authors: Mancini L, Ciccarelli O, Manfredonia F, Thornton JS, Agosta F, Barkhof F, Beckmann C, De Stefano N, Enzinger C, Fazekas F, Filippi M, Gass A, Hirsch JG, Johansen-Berg H, Kappos L, Korteweg T, Manson SC, Marino S, Matthews PM, Montalban X, Palace J, Polman C, Rocca M, Ropele S, Rovira A, Wegner C, Friston K, Thompson A, Yousry T

source: Neuroimage. 2009 Apr 1;45(2):500-11

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Predicting accidental falls in people with multiple sclerosis -- a longitudinal study

In this longitudinal study the authors investigated the factors associated with a higher risk of episodes of falls and near falls in a population with MS, as these episodes provoke a severe decrease in the quality of life of these people. Lower level of mobility, higher degree of spasticity and loss of proprioception were all factors strongly associated with a high risk of falls.

authors: Nilsagård Y, Lundholm C, Denison E, Gunnarsson LG

source: Clin Rehabil. 2009 Mar;23(3):259-69

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The multiple sclerosis severity score (MSSS) predicts disease severity over time

In 2005 a new score to assess the severity of MS called MSSS was proposed. It took into account the increase of disability and the time needed to reach it. Nevertheless it was not clarified whether it could be used for individual patients or whether it could be used as a tool to monitor treatment effect. In this study the authors showed that the MSSS can be used not only to predict the accrual of disability over time in individual patients but also to assess the efficacy of treatment in a given patient as well as in groups.

authors: Pachner AR, Steiner I

source: J Neurol Sci. 2009 Mar 15;278(1-2):66-70

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Boost for safe stem cell treatment

source: MS Resource Centre UK

Scientists in Britain and Canada have overcome the biggest obstacle to safe treatments with all-purpose stem cells, created directly from a patient’s own skin.

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Positive results published of first of two phase 3 clinical trials of Fampridine-SR

source: US National MS Society

Walking speed improved significantly in a phase 3 clinical trial of people with MS taking oral Fampridine-SR, a drug designed to provide symptomatic relief by compensating for lost nerve conduction.

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"Move It" to create a world free of MS - US National MS Society awareness week, 2 – 8 March 2009

source: US National MS Society

The 2009 MS awareness week of the US National MS Society (NMSS) has been supported by a Congressional Resolution.

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Multiple Sclerosis Society India, Delhi chapter, to hold 20th anniversary fundraising event

source: MS Society of India

Multiple Sclerosis Society India (MSSI), Delhi chapter, is organising a fundraising event on 15 March 2009.

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