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Making Connections
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MSIF News
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| Summaries of new MSIF activities, events, projects, programmes, resources, publications and more. |
MS in focus online survey – take part now!
This Survey is now closed
In case you missed it previously, please help inform the next edition of our biannual magazine, MS in focus, by taking part in our survey about the disease courses (types) of MS.
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Profile of the Month
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| Summaries of news, views and achievements from people with MS around the world. |
Profile of the Month : January 2010
Reni de Boer
Country: Netherlands
Age: 29
Type of MS: relapsing-remitting
Year of Diagnosis: 2004
"I am happy to be acting in MSIF’s awareness raising video for World MS Day and am proud to be playing a part in raising more awareness for the 2 million people worldwide with MS."
Profile of the month: May 2009
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Research News
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| Summaries of all the latest research findings on MS selected by a team based at the Institute of Neurology, London. |
The relationship between handedness and risk of multiple sclerosis
MS is a complex disease. A potential relationship between sex hormones and risk of MS and other autoimmune disease has been suggested by their role in the modulation of immune response. In addition, left-handedness has also been related to different exposure to intrauterine sex hormones. The authors of this study aimed to investigate whether, in an exclusive female population, left-handed women had a higher risk of developing MS. They found that the risk of MS was slightly higher among left-handed women.
authors: Gardener H, Munger K, Chitnis T, Spiegelman D, Ascherio A
source: Mult Scler. 2009 May;15(5):587-92
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Association between MRI parameters and the MS severity scale: a 12 year follow-up study
A few years ago, a new scale to measure the severity of MS was proposed, due to its high reliability in describing the gain of disability over time. The authors of this study have found that certain MRI parameters, such as lesion load (measured by the T1 sequence), and brain volume loss, that measured by this relatively new scale, are capable of predicting the forthcoming severity of the disease.
authors: Minneboo A, Uitdehaag B, Jongen P, Vrenken H, Knol D, van Walderveen M, Polman Ch, Castelijns J, Barkhof F
source: Mult Scler. 2009 May;15(5):632-7
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Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with the secondary progressive subtype
One of the main objectives of MS imaging is to find markers to identify people who will develop further disability and those who will remain stable. The authors of this study have found an association between specific features in the MRI, which consists of an enhancement of a grey matter nucleus located deep in the brain, with having developed the secondary phase of the disease and with higher disability, though the precise pathologic mechanism is not known. Even though these results must be interpreted cautiously, as this is a cross-sectional study, they may help us to better understand the underlying processes and to develop markers of progression.
authors: Roccatagliata L, Vuolo L, Bonzano L, Pichiecchio A, Mancardi GL
source: Radiology. 2009 May;251(2):503-10
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Opportunistic infections and other risks with newer multiple sclerosis therapies
Over the last few years a number of new treatments for MS have been developed, some of which are already in use. Although there is a high degree of optimism regarding these new treatments, as they have shown great results in clinical trials, some new risks have appeared. There is a risk of opportunistic infections, infections that generally appear when the immune system is not fully working, as these new drugs may strongly alter the immune system. In this article Berger reviews the different opportunistic infections and other risks that may appear in people who are receiving these new treatments.
authors: Berger JR, Houff S
source: Ann Neurol. 2009 Mar 19;65(4):367-377
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Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: Observations from a post-mortem 3 Tesla imaging study
Even though MS is a disease mainly affecting the white matter, there is increasing evidence that the grey matter (GM) may also be affected and that this GM involvement may also contribute to the increase of disability. However, the detection of grey matter lesions is very difficult with the conventional MRI techniques. In this study the authors have studied, by means of three different non-conventional MRI techniques, the post-mortem brain tissue from a man who had suffered from MS for a long time. They concluded that the combination of the three different MRI techniques tested was crucial for detecting cortical grey matter lesions. They also suggested that this combination could be helpful in clinical practice.
authors: Bagnato F, Yao B, Cantor F, Merkle H, Condon E, Montequin M, Moore S, Quezado M, Tkaczyk D, McFarland H
source: J Neurol Sci. 2009 Apr 22
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MS News
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Multiple Sclerosis International Federation
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Tel: +44 (0) 20 7620 1911
Fax: +44 (0) 20 7620 1922
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