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Making Connections
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| Summaries of new MSIF activities, events, projects, programmes, resources, publications and more. |
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| Summaries of news, views and achievements from people with MS around the world. |
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Research News
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| Summaries of all the latest research findings on MS selected by a team based at the Institute of Neurology, London. |
Effect of immigration on multiple sclerosis sex ratio in Canada: the Canadian collaborative study
MS is a complex disease in which genes and environment play a role. MS affects more women than men, especially in countries where there is a higher prevalence of MS, such as Canada, where this study took place. In terms of incidence of MS, the difference between women and men seems to be increasing over time. The authors aimed to investigate whether the country of origin and the age of migration had an impact on the sex ratio. Amongst immigrants with MS they found that the proportion of females was higher in people from countries of high latitude and the proportion of females was higher when the age of migration was below 21. These findings suggest that the environment plays a very important role in the female sex predominance of MS.
authors: Orton SM, Ramagopalan SV, Brocklebank D Miss, Herrera BM, Dyment DA, Yee IM, Sadovnick AD, Ebers GC
source: J Neurol Neurosurg Psychiatry. 2009 Aug 25
read more
Neurofunctional correlates of personality traits in relapsing-remitting multiple sclerosis: An fMRI study
Personality traits can influence social and cognitive functioning. It is thought that personality traits may influence the quality of life of people with MS, since they can determine how a person copes with diagnosis and other MS related issues. This study aimed to assess how functional magnetic resonance imaging (fMRI), a specific sequence of MRI which describes the activation of the different cortical areas of the brain, can identify different personality traits in a group of people with an early MS diagnosis and a group of healthy controls. The authors found that different personality traits were associated with different patterns of fMRI therefore the underlying pathology of these personality traits was preserved in people with MS, at least in early stages of the disease.
authors: Gioia MC, Cerasa A, Valentino P, Fera F, Nisticò R, Liguori M, Lanza P, Quattrone A
source: Brain Cogn. 2009 Aug 19
read more
Regional white matter atrophy-based classification of multiple sclerosis in cross-sectional and longitudinal data
The underlying processes responsible for the progression of disability in MS, which may depend on the MS type, are not fully understood. The authors aimed to investigate whether the volume in two different regions of white matter of the brain could be used to differentiate amongst different MS subtypes. Based on the results, the authors created an algorithm to classify people with different types of MS, based on the different volumes of white matter regions of the brain, since people with relapsing-remitting MS had higher volumes than people with progressive forms of MS. In this latter group, people with secondary progressive MS had lower volumes than people with primary progressive MS. This study may have important consequences from a clinical point of view and could help to shed light on the underlying biology of MS.
authors: Sampat MP, Berger AM, Healy BC, Hildenbrand P, Vass J, Meier DS, Chitnis T, Weiner HL, Bakshi R, Guttmann CR
source: AJNR Am J Neuroradiol. 2009 Aug 20
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Correlation between disability and transcranial magnetic stimulation abnormalities in patients with multiple sclerosis
Some people with MS may experience a progression of their symptoms over time. However, the exact mechanisms underlying this progression are not fully understood and it is difficult to predict whose symptoms will worsen and whose will remain stable. The authors studied a group of people with MS, with and without clinical signs of motor dysfunction, and a group of healthy controls, using transcranial magnetic stimulation (TMS). TMS is a physiological test which measures the damage of motor pathways of the central nervous system by measuring the speed of nerve fibre conduction and other related parameters. They found that people with MS had abnormal results in the TMS compared to the controls. The authors also found that people with a higher level of disability had more severe TMS abnormalities. The results demonstrate that TMS may be a useful tool in measuring progression in MS and better understanding the underlying processes responsible for disability in MS.
authors: Kale N, Agaoglu J, Onder G, Tanik O
source: J Clin Neurosci. 2009 Aug 18
read more
MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis
Magnetic resonance (MR) imaging in MS has undergone an important expansion over recent years and new techniques have been developed. MR spectroscopic imaging of the brain consists of the analysis of certain molecules which are known to play specific roles in the normal function of the brain or whose presence (or absence) has been associated with neuronal damage. Sometimes the molecules, such as glutathione, which are involved in the normal processes of detoxification in brain cells, are hard to identify with conventional spectroscopic sequences (i.e. with currently used field strengths). It is known that the detoxification processes in the brain may have an influence on the long-term prognosis in MS, and the detection of markers of good functioning in detoxification processes might become a tool to predict future outcome in people with MS. The authors aimed to quantify the glutathione with MR spectroscopy at a very high field strength in the grey and white matter of the brain, in a group of healthy controls and a group of people with MS. They found that glutathione levels were significantly lower in the group of people with MS. These preliminary results help us to better understand the complex pathological processes in MS, although further studies regarding this marker are needed.
authors: Srinivasan R, Ratiney H, Hammond-Rosenbluth KE, Pelletier D, Nelson SJ
source: Magn Reson Imaging. 2009 Aug 18
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MS News
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| Summaries of MS news from websites around the world. |
Blood test may predict course of MS
source: UK MS Society
Scientists have discovered a blood test that could predict the course of MS, or even indicate who is likely to develop the condition after a first MS-like attack.
read more
Fast Forward contracts with IntraLinks
source: US National MS Society
Fast Forward, the US National MS Society’s subsidiary devoted to bridging the gap between research and drug development, has chosen IntraLinks, a leading provider of critical information exchange solutions to help streamline the collection, distribution and tracking of information needed to support its funding of multiple biotechnology and pharmaceutical companies who are working on new MS treatments.
read more
Fast Forward and Amplimmune join forces
source: US National MS Society
Fast Forward, the US National MS Society’s subsidiary devoted to bridging the gap between research and drug development, has announced a collaboration with biotechnology company Amplimmune to support the development of AMP-110, an innovative treatment for MS and other autoimmune diseases.
read more
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Multiple Sclerosis International Federation
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