Recent preliminary studies have suggested that CCSVI, a reported abnormality in blood drainage from the brain and spinal cord, may contribute to nervous system damage in MS.

This hypothesis has been put forth by Dr Paolo Zamboni from the University of Ferrara in Italy. Based on the results of preliminary findings from a study of approximately 65 patients, published in June 2009, Dr Zamboni and colleagues stated that this pilot study warrants a larger and better controlled study to definitively evaluate the possible impact of CCSVI on the disease process in MS.

The risks and benefits of procedures to treat CCSVI have not been established by properly controlled clinical trials. Unless and until strong supportive evidence is produced, and until the risks of treatment are thoroughly assessed, any procedures to mechanically correct the purported problem outside of a clinical trial are not recommended.

Several MS societies are promoting further research in CCSVI as a matter of urgency. MSIF will continue to facilitate an open exchange of information amongst its members on the issue.

Read the statement


CCSVI reports at ECTRIMS 2010
Two platform presentations and 14 posters focused on issues surrounding CCSVI and multiple sclerosis, presenting mixed or conflicting results. In addition, the Charcot Foundation convened a Satellite Symposium focused on CCSVI before the official start of ECTRIMS (for which abstracts are not available).
Read the NMSS summary of CCSVI studies presented at ECTRIMS here (scroll down to CCSVI and MS).

CCSVI publications
New studies and perspectives on CCSVI and MS are being published at an increasing rate. Click here to search for recent studies on PubMed, a service of the U.S. National Library of Medicine.