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summary: It has been suggested that vitamin D may play an important role in the pathogenesis of MS, and that its immunomodulatory effects might be carried out by the vitamin D present within the central nervous system. However, the authors did not find differences in vitamin D levels of the cerebrospinal fluid (CSF) between people with MS and people with other neurological, inflammatory and non-inflammatory diseases. Also, they did not find differences in vitamin D levels of the CSF between people with MS, with or without clinical or MRI inflammatory activity, suggesting that vitamin D does not have a major impact on disease activity.
authors: Holmøy T, Moen SM, Gundersen TA, Holick MF, Fainardi E, Castellazzi M, Casetta I
source: Mult Scler. 2009 Oct 6
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category: Immunology
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glossary:
Central nervous system
Cerebrospinal fluid (CSF)
Gene
Immunoglobulin
Immunosuppressio
Magnetic Resonance Imaging (MRI)
Multiple sclerosis
Nervous system
Relapse
Remission
Sclerosis
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