summary: A major pathological hallmark of multiple sclerosis (MS) is the presence of demyelinated lesions in the central nervous system. Specific cells, termed astrocyctes can become activated and migrate contributing to local damage. The authors studied this process and how some extracellular proteins can be involved. They found that a protein (Transglutaminase 2), localized on the surface of astrocytes, could play an important role in contributing to adhesion, migration and thus in tissue remodelling and glial scarring.

authors: van Strien ME, Drukarch B, Bol JG, van der Valk P, van Horssen J, Gerritsen WH, Breve JJ, van Dam AM.

source: Brain Pathol. 2010 Aug 20

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