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  Autoantibody-mediated demyelination depends on complement activation but not activatory Fc-receptors

summary: This study clarifies the role of antibodies in demyelination in the mouse model of MS by showing that they exert their action through activation of complement rather than via T-cells.

authors: Urich E, Gutcher I, Prinz M, Becher B.

source: Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18697-702. Epub 2006 Nov 22

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category: Immunology

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glossary:

    Antibodies
    Antigen
    Cell
    Demyelination
    Myelin
    Physical
    Receptors
    T-cell
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