summary: This paper describes findings on 50 subjects with benign and 50 subjects with early RR MS, who underwent conventional and magnetisation transfer imaging. Magnetisation transfer ratio (MTR), a measure of tissue damage, was lower in lesions in RRMS than benign MS, and lower in benign MS than in healthy controls. MTR was lower in normal appearing white and grey matter in RRMS, but similar to healthy controls in benign MS. These findings suggest that benign MS is a true subtype of MS where only relatively mild tissue damage is apparent.

authors: De Stefano N, Battaglini M, Stromillo ML, Zipoli V, Bartolozzi ML, Guidi L, Siracusa G, Portaccio E, Giorgio A, Sorbi S, Federico A, Amato MP.

source: Brain. 2006 Aug;129(Pt 8):2008-16. Epub 2006 Jun 30

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