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  Determinants of CCL5-driven mononuclear cell migration across the blood-brain barrier. Implications for therapeutically modulating neuroinflammation

summary: The authors developed a test-tube model of the blood-brain barrier found in humans to study how this breaks down in MS, clarifying some of the immunologically active molecules which could be potential targets for therapy.

authors: Ubogu EE, Callahan MK, Tucky BH, Ransohoff RM.

source: J Neuroimmunol. 2006 Jul 18; [Epub ahead of print]

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category: Cell Biology

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glossary:

    Blood-brain barrier
    Brain
    Cell
    Computerized
    Immunoglobulin
    Immunosuppressio
    Inflammation
    Molecule
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