summary: In this interesting study examining the sera of of 325 MS patients, 69 patients with clinically isolated syndrome and 164 healthy controls for reactivity to 3 different isoforms of myelin oligodendrocyte glycoprotein (MOG), a putative autoantigen in MS, the authors report that in patients with relapsing-remitting MS high-titres of anti-MOG IgG correlated with disability (evaluated by EDSS) but that the vast majority of samples contained only low titres of anti-MOG.

The authors found that MOG reactivity is non-ubiquitous, as seen in other studies, and conclude that in patients with high-titres are likely to represent a higher affinity of antibodies against pathologically relevant MOG epitopes, that are only present in a small proportion of patients with MS.

authors: Menge T, Lalive PH, von Budingen HC, Genain CP.

source: J Neuroinflammation. 2011 Nov 17;8(1):161. [Epub ahead of print]

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