summary: Clinical evolution in MS may vary widely amongst individuals, and the prediction of long-term clinical outcome is still far from satisfactory. It is well known that some people with MS may develop, with time, some degree of cognitive dysfunction. In this longitudinal study of people with MS, the authors found that a poorer cognitive performance, early in the disease, on tasks assessing verbal memory and information processing speed, was associated with a more rapid clinical worsening over the following years. The results of this study shed some light on the search for clinically relevant predictive markers of future disability, which can be very useful in adapting therapeutic strategies in the early stages of MS.

authors: Deloire M, Ruet A, Hamel D, Bonnet M, Brochet B

source: Mult Scler. 2010 Mar 1

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category: Epidemiology

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