summary: Previous studies showed that the presence of certain genetic variants (HLA27) were associated with higher lesion load and lower brain volume in MS. Besides this, it is known that a history of Epstein-Barr virus infection in people with MS is associated with higher loss of grey matter. The authors of this study have investigated the interaction between EBV infection and these risk genetic variants and they have suggested that this interaction is associated with both lesion burden and development of brain volume loss.

authors: Zivadinov R, Weinstock-Guttman B, Zorzon M, Uxa L, Serafin M, Bosco A, Bratina A, Maggiore C, Grop A, Tommasi MA, Srinivasaraghavan B, Ramanathan M

source: J Neuroimmunol. 2009 Feb 14

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category: Virology
category: Genetics

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