summary: Predisposition to MS seems to be influenced by environmental and genetic factors. Certain variations of a number of genes have been associated with a higher risk of developing MS, most of them being related to the immune system. In this study, two previously unidentified regions of the DNA, located on chromosomes 12 and 20, have been associated with the risk of developing MS. These DNA regions have also been associated with the risk of developing other autoimmune diseases.

authors: The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene); Study design and management committee:, Bahlo M, Booth DR, Broadley SA, Brown MA, Foote SJ, Griffiths LR, Kilpatrick TJ, Lechner-Scott J, Moscato P, Perreau VM, Rubio JP, Scott RJ, Stankovich J, Stewart GJ, Taylor BV, Wiley J; Sample processing, data handling and genotyping:, Brown MA, Booth DR, Clarke G, Cox MB, Csurhes PA, Danoy P, Drysdale K, Field J, Foote SJ, Greer JM, Griffiths LR, Guru P, Hadler J, McMorran BJ, Jensen CJ, Johnson LJ, McCallum R, Merriman M, Merriman T, Pryce K, Scott RJ, Stewart GJ, Tajouri L, Wilkins EJ, Rubio JP; Data analysis:, Bahlo M, Brown MA, Browning BL, Browning SR, Perera D, Rubio JP, Stankovich J; Phenotyping:, Broadley S, Butzkueven H, Carroll WM, Chapman C, Kermode AG, Marriott M, Mason D, Heard RN, Pender MP, Slee M, Tubridy N, Lechner-Scott J, Taylor BV, Willoughby E, Kilpatrick TJ.

source: Nat Genet. 2009 Jun 14

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