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summary: In this study by Greek researchers, the authors report that granulocytic myeloid-derived suppressor cells (G-MDSCs) abundantly accumulate within the peripheral lymphoid compartments and target organs of mice with experimental autoimmune encephalomyelitis prior to disease remission. Additionally, when G-MDSCs were transferred in vivo they produced an improvement in clinical outcome, delayed disease onset and significantly decreased demyelination. The results are interesting and the authors propose that these cells may be exploited for therapeutic purposes.
authors: Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P.
source: J Immunol. 2011 Dec 30. [Epub ahead of print]
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category: Immunology
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glossary:
Autoimmune disease
Cell
Central nervous system
Demyelination
Experimental
Lymph
Myelin
Myelitis
Nervous system
Peripheral
Remission
Sign
Suppressor
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