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  Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes

summary: This study provides strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies.

authors: Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R.

source: J Neurosci. 2006 Aug 2;26(31):8206-16.

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category: Immunology

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glossary:

    Axon
    Cell
    Gene
    Glial cells
    Multiple sclerosis
    Myelin
    Oligodendrocyte
    Oligodendrocyte
    Sclerosis
    Sign
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