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summary: Activation of transcription factor NF-kappaB in the central nervous system (CNS) has been linked to autoimmune demyelinating disease. This study demonstrates that NF-kappaB-dependent gene expression in non-microglial cells of the CNS provides a permissive proinflammatory milieu that is critical for CNS inflammation and tissue damage in autoimmune demyelinating disease.
authors: van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M.
source: Nat Immunol. 2006 Aug 6; [Epub ahead of print]
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category: Immunology
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glossary:
Cell
Central nervous system
Gene
Glial cells
Inflammation
Microglia
Myelin
Myelitis
Nervous system
Physical
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