summary: In this large study the authors aimed to test the validity of a score called weighted genetic risk score (wGRS) to predict the risk of developing MS. The authors found that this score, which relies on the analysis of different genes that have been proven to be related to MS, can modestly predict MS risk. More interestingly, this score was enhanced when non-genetic risk factors were included into a more comprehensive algorithm to predict MS risk.

authors: De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P; the steering committees of the BENEFIT, BEYOND, LTF, and CCR1 studies, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA, Karlson EW

source: Lancet Neurol. 2009 Oct 28

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category: Genetics

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