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  IVIG enters the central nervous system during treatment of experimental autoimmune encephalomyelitis and is localised to inflammatory lesions.

summary: This study investigated the role of Intravenous immunoglobulin (IVIG) in reducing relapses in RRMS, using a rat model of MS. It was found that IVIG can only cross the blood brain barrier into the CSF (fluid around the brain) in areas where the barrier is damaged by inflammation.

authors: Jorgensen SH, Storm N, Jensen PE, Laursen H, Sorensen PS.

source: Exp Brain Res. 2006 Nov 8; [Epub ahead of print]

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category: Clinical Trials and Therapeutics

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glossary:

    Brain
    Central nervous system
    Cerebrospinal fluid (CSF)
    Experimental
    Immunoglobulin
    Immunosuppressio
    Inflammation
    Intravenous
    Lesion
    Myelitis
    Nervous system
    Plaque
    Relapse
    Relapsing/remitting MS
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