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summary: More work on the role of sodium channels in damage and repair of myelin, this study focuses on the channels themselves and finds that clustering is the first event in repair. The authors hypothesize that defects in sodium channel clustering may be responsible for some of the incomplete remyelination seen in MS.
authors: Coman I, Aigrot MS, Seilhean D, Reynolds R, Girault JA, Zalc B, Lubetzki C.
source: Brain. 2006 Dec;129(Pt 12):3186-95. Epub 2006 Jun 9.
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category: Pathology
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glossary:
Axon
Demyelination
Multiple sclerosis
Myelin
Proteins
Remyelination
Sclerosis
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