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  Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE

summary: This mouse study demonstrates that phenytoin, a drug which blocks sodium channels, is effective in preventing axonal damage in mouse models of MS.

authors: Black JA, Liu S, Hains BC, Saab CY, Waxman SG.

source: Brain. 2006 Dec;129(Pt 12):3196-208. Epub 2006 Aug 24.

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category: Clinical Trials and Therapeutics

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glossary:

    Animal models
    Axon
    Chronic
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