summary: This new, interesting study aimed to correlate the antibody indices for the neurotropic viruses; measles virus, rubella virus, and varicella zoster virus with T2 lesion load in patients with clinically isolated syndrome and early relapsing remitting multiple sclerosis. The results show that intrathecal measles virus IgG production correlates with disease activity seen on spinal and brain MRI in patients with early disease. A similar correlation was seen with varicella zoster virus but this did not reach statistical significance. The authors comment that the reactions to these viruses form part of the polyspecific immune reaction in MS and may be of possible prognostic impact on MRI and clinical outcomes.

authors: Rosche B, Laurent S, Conradi S, Hofmann J, Ruprecht K, Harms L.

source: PLoS One. 2012;7(1):e28094. Epub 2012 Jan 19.

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category: Immunology

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