summary: The authors from Boston, USA, report an improvement in the sensitivity for detecting longitudinal change of their previously described,'magnetic resonance disease severity scale (MRDSS), which combines measurements of T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF). A longitudinal study comparing the composite scale to its component parts showed that change in MRDSS was larger than the change in MRI subcomponents. MRDSS is reported to have particularly high sensitivity in relapsing-remitting MS.

authors: Moodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han XM, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CR, Weiner HL, Neema M, Bakshi R.

source: J Neurol Sci. 2011 Dec 28. [Epub ahead of print]

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