summary: Although the presence of severe symptoms of cognitive dysfunction in MS is not frequent or typical, the identification of those with a high risk of developing these symptoms may be crucial. The authors studied 23 people with MS with severe cognitive dysfunction. They found that the clinical feature most frequently observed amongst them was the presence of psychiatric symptoms and the presence of signs denoting involvement of the brain cortex. With this study, the authors pinpoint the importance of the grey matter involvement in MS, especially when cognitive dysfunction appears, as many authors have already suggested.

authors: Staff NP, Lucchinetti CF, Keegan BM

source: Arch Neurol. 2009 Sep;66(9):1139-43

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category: Epidemiology

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