summary: Even though MS is a disease mainly affecting the white matter, there is increasing evidence that the grey matter (GM) may also be affected and that this GM involvement may also contribute to the increase of disability. However, the detection of grey matter lesions is very difficult with the conventional MRI techniques. In this study the authors have studied, by means of three different non-conventional MRI techniques, the post-mortem brain tissue from a man who had suffered from MS for a long time. They concluded that the combination of the three different MRI techniques tested was crucial for detecting cortical grey matter lesions. They also suggested that this combination could be helpful in clinical practice.

authors: Bagnato F, Yao B, Cantor F, Merkle H, Condon E, Montequin M, Moore S, Quezado M, Tkaczyk D, McFarland H

source: J Neurol Sci. 2009 Apr 22

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