summary: In MS, an inflammatory-demyelinating disease of the central nervous system (CNS), degenerated myelin is believed to trigger deleterious inflammatory reactions in the brain. The authors demonstrated that in animal models of MS, degenerated myelin can also cause undesirable inflammation in the spinal cord, through the activation of a specific pathway. The findings of this study suggest that clearance of degenerated myelin or the blockage of such activated pathways might be considered, in future, as possible treatment strategies.

authors: Sun X, Wang X, Chen T, Li T, Cao K, Lu A, Chen Y, Sun D, Luo J, Fan J, Young W, Ren Y

source: PLoS One. 2010 Feb 23;5(2):e9380

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category: Pathology
category: Immunology

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