summary: This paper is a review of the current status of basic science and clinical research related to the therapeutic targeting of voltage-gated K(+) channels (K(v)) in MS. Covered are (1) K(v) channel nomenclature, structure, function, and pharmacology; (2) classic and current experimental morphology and neurophysiology studies of demyelination and conduction deficits; and (3) a comprehensive overview of clinical trials utilizing 4-AP and 3,4-DAP in MS patients.

authors: Judge SI, Bever CT Jr

source: Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9.

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category: Clinical Trials and Therapeutics

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