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summary: This paper reviews the role of oral methotrexate in MS. Two randomized controlled trials were identified. Although one of these trials reported a non-significant reduction in sustained Expanded Disability Status Scale (EDSS) progression and number of relapses, further trials are required in both relapsing-remitting and progressive groups to establish the role of oral methotrexate in MS.
authors: Gray OM, McDonnell GV, Forbes RB.
source: Mult Scler. 2006 Aug;12(4):507-10.
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category: Clinical Trials and Therapeutics
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glossary:
Disability
Expanded
Multiple sclerosis
Relapse
Relapsing/remitting MS
Sclerosis
Sign
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