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summary: This study in a mouse model of MS again demonstrates the role of the innate immune cells, this time in grey matter lesions, which have been linked to clinical progression in MS. The study suggests that microglial activation persists through the chronic disease phase, while peak T cell responses are known to be associated with acute inflammation.
authors: Rasmussen S, Wang Y, Kivisäkk P, Bronson RT, Meyer M, Imitola J, Khoury SJ.
source: Brain. 2007 Nov;130(Pt 11):2816-29. Epub 2007 Sep 22.
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category: Pathology
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glossary:
Acute
Anticholinergic
Cell
Chronic
Combined
Experimental
Glial cells
Grey matter
Inflammation
Lesion
Microglia
Multiple sclerosis
Myelitis
Neuron
Plaque
Sclerosis
T-cell
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