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summary: This study in a rat model of MS found that regulatory T cells were able to prevent the autoimmune attack of the central nervous system by preventing pathogenic T cells crossing the blood brain barrier. This regulation occurred outside the brain in the spleen.
authors: Tischner D, Weishaupt A, van den Brandt J, Muller N, Beyersdorf N, Ip CW, Toyka KV, Hunig T, Gold R, Kerkau T, Reichardt HM.
source: Brain. 2006 Oct;129(Pt 10):2635-47. Epub 2006 Aug 18.
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category: Immunology
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glossary:
Brain
Cell
Central nervous system
Multiple sclerosis
Nervous system
Sclerosis
T-cell
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