summary: In this preliminary study from America, the authors investigated the safety and effectiveness of high-dose cyclophosphamide, a treatment which strongly suppresses the immune system, in people with aggressive relapsing-remitting MS. They found that this treatment was generally well tolerated and reduced disability and inflammation on MRI. Further larger studies are needed.

authors: Krishnan C, Kaplin AI, Brodsky RA, Drachman DB, Jones RJ, Pham DL, Richert ND, Pardo CA, Yousem DM, Hammond E, Quigg M, Trecker C, McArthur JC, Nath A, Greenberg BM, Calabresi PA, Kerr DA.

source: Arch Neurol. 2008 Jun 9. [Epub ahead of print]

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