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  Relapses in multiple sclerosis are associated with increased CD8(+) T-cell mediated cytotoxicity in CSF.

summary: The authors investigated the role of CD8+ T-cells, which are involved in the immune system, in the pathogenesis of MS. They found that the activity of these cells in the spinal fluid of people with relapsing-remitting MS increases during clinical episodes, and this continues for some months afterwards.

authors: Malmeström C, Lycke J, Haghighi S, Andersen O, Carlsson L, Wadenvik H, Olsson B.

source: J Neuroimmunol. 2008 Apr 5 [Epub ahead of print]

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category: Immunology

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glossary:

    Cell
    Cerebrospinal fluid (CSF)
    Gene
    Immune system
    Multiple sclerosis
    Relapse
    Relapsing/remitting MS
    Sclerosis
    T-cell
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