summary: This article describes a 13-year longitudinal study in 30 patients. The authors show that T2 lesions in relapsing-remitting MS correlate strongly with brain tissue loss and brain tissue integrity 13 years later, and with clinical disease severity, though age significantly impacts the clinical correlation. The results provide direct evidence for the disability threshold hypothesis in MS and support monitoring T2 lesions in relapsing-remitting MS.

authors: Rudick RA, Lee JC, Simon J, Fisher E.

source: Ann Neurol. 2006 Jun 19; [Epub ahead of print]

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