These drugs are widely used to reduce inflammation, especially in arthritis. Proper evaluation of this type of drug in MS has not been done. A small study, however, suggests that ibuprofen is safe, although not effective in reducing the volume of active MS lesions seen on MRI. Ibuprofen and aspirin are being used to reduce early flu-like side-effects of interferon beta and appear to be safe for the relief of discomfort.

In the opinion of the Committee, there appears to be no scientific basis for use of this therapy other than for the relief of early side-effects associated with interferon therapy.