35 years ago, short-term intramuscular (IM) adrenocorticotropic hormone ACTH given daily in high doses was shown to reduce the severity and shorten the duration of exacerbations. In more recent studies, claims have been made that IVMP works more quickly and effectively than ACTH, and most neurologists now prefer this treatment.

In the opinion of the Committee, intramuscular ACTH, although proven efficacious, is no longer the preferred treatment for MS exacerbations.